01 · HAIR FOLLICLE SIGNAL TRIGGERS & ROS

Hair Follicle Signal Triggers

Exposome Factors

  • Pollution
  • UV
    radiation
  • Smoking
  • Diet
  • Stress
  • Poor sleep
  • Temperature
    fluctuations
  • Inflammation
  • Hormonal
    changes
  • Metabolic
    imbalance
ROS
INHIBITS

HAIR FOLLICLE

02 · FOLLICLE SIGNALING & HAIR-CYCLE SUPPORT

Bio-Responsive Hair Follicle Signaling

Scroll sideways to explore the pathway.

The reference pathway shows Morphagen activating Sonic hedgehog (SHH). SHH inhibits Patched (PTCH), supporting Smoothened (SMO) and GLI signaling. GLI connects to Cyclin D and the hair cycle. Sensory nerves and patchouli alcohol connect to OR2AT4, followed by G-protein, cAMP, Cyclin D and the hair cycle. Upward arrows indicate increased signaling.

EPIDERMIS
MorphagenTM
Patched (PTCH)
Smoothened
(SMO)  ↑
Sonic hedgehog
(SHH)  ↑
GLI  ↑
Cyclin D  ↑
Hair Cycle  ↑
Sensory nerves
OR2AT4  ↑
G-protein  ↑
cAMP  ↑
Pogostemon cablin
Patchouli alcohol
ACTIVATES
INHIBITS
Ligand binding
Ligand binding

Healthier Hair Growth. Stronger Follicle Vitality.

Supports follicle stem-cell-associated hair growth and healthier cycling.

A&S MorphagenTM · Visible Hair Benefit Profile

Six benefit areas supporting healthier-looking hair and scalp vitality.

Healthier-looking
hair growth

Helps support visible hair growth and vitality.

01 · HAIR GROWTH

Fuller-looking
hair

Supports a denser, more voluminous-looking appearance.

02 · FULLER-LOOKING HAIR

Hair cycle
support

Helps support a healthy active hair cycle.

03 · HAIR CYCLE

Follicle vitality

Supports follicle stem-cell-associated renewal signaling.

04 · FOLLICLE VITALITY

Scalp balance

Helps support balanced scalp comfort and resilience.

05 · SCALP BALANCE

Reduced visible
thinning

Helps improve the look of miniaturization-related thinning.

06 · VISIBLE THINNING

HAIR GROWTH · ACTIVE CYCLING · FOLLICLE VITALITY · SCALP RESILIENCE