01 · Exposome Stressors & Epidermal Activation

Exposome — Sensitive Skin Stressors

  • Heat
  • Chemicals
  • Microbes
  • UVB
  • Stress
Epidermis(Keratinocytes)
TLR increasedTRP family increased
MRGPRX2

02 · Bio-Responsive Modulation & Skin Comfort

Bio-Responsive Modulation

MeraxylTM
Gα decreased
MRGPRX2Ca2+ decreased
NF-κB decreased
Reduced
mast-cell
histamine release

Effector Mediator System

  • Degranulation decreased
  • Cytokines decreased
  • Chemokines decreased
  • Skin inflammation decreased
  • Immune response decreased
  • Itch decreased
  • Allergies / sensitivity decreased

Calmer Sensitive Skin. Improved Comfort.

  • Reduced mast-cell reactivity
  • Lower inflammatory signaling
  • Better skin comfort
  • Support for sensitive skin resilience

A&S Meraxyl™ · Long-Term Skin Benefit Profile

Six benefit areas reorganized into a concise two-row web layout.

Reduced Skin Sensitivity

Helps reduce sensitivity to external stressors.

01 · Skin sensitivity

Reduced Itch Discomfort

Helps calm itch-associated signaling.

02 · Itch comfort

Calmer Neuroimmune Reactivity

Helps modulate neuroimmune activation.

03 · Neuroimmune

Balanced Immune Response

Supports immune balance and adaptive responses.

04 · Immune balance

Reduced Inflammation

Helps lower inflammatory cytokine production.

05 · Inflammation

Improved Skin Comfort & Resilience

Promotes healthy-looking, comfortable, resilient skin.

06 · Comfort & resilience

Skin Comfort · Immune Balance · Neuroimmune Modulation · Well-Being